Recombinant Human Apo-Transferrin | CAS 11096-37-0 | High Purity GMP-Grade

Animal-Free | Chemically Defined | Bulk Supply for Industrial Biomanufacturing

Product Overview

Recombinant Human Apo-Transferrin (rHu Apo-Tf, CAS 11096-37-0) is a high-purity, iron-free recombinant glycoprotein engineered as a critical raw material for serum-free and chemically defined cell culture systems. Produced via state-of-the-art recombinant expression technology with zero animal-derived components, this product delivers consistent iron transport functionality while eliminating the safety risks and batch-to-batch variability inherent to plasma-derived transferrin.

As an essential nutrient factor for mammalian cell metabolism, Apo-Transferrin mediates cellular iron uptake through the transferrin receptor (CD71) pathway, supporting sustained cell proliferation, maintaining redox homeostasis, and scavenging free metal ions in culture media. Our recombinant formulation is optimized for large-scale biopharmaceutical manufacturing, stem cell expansion, and advanced therapy production workflows.

Key Advantages for Industrial & Enterprise Customers

I. Animal-Origin-Free (AOF) Regulatory Compliance

• 100% recombinant expression system with no human or animal plasma components
• Eliminates risk of adventitious agents (viruses, prions, mycoplasma)
• Streamlines regulatory submissions for biologic products (FDA, EMA, NMPA)
• Full traceability from gene sequence to final batch release

II. Unmatched Batch-to-Batch Consistency

• Tightly controlled manufacturing process with standardized purification protocols
• Minimal lot-to-lot variation ensures stable bioprocess performance
• Ideal for long-term production campaigns and scale-up from R&D to commercial manufacturing
• Full characterization data provided with every batch (CoA, MS, HPLC, endotoxin testing)

III. Superior Purity & Verified Bioactivity

• ≥98% purity confirmed by SDS-PAGE and HPLC
• Endotoxin level ≤0.5 EU/mg protein, tested by Sol-Gel method
• Preserved native iron-binding capacity and receptor-binding affinity
• Functionally validated through cell proliferation assays

IV. Cost-Effective Bulk Supply Capacity

• Scalable production supporting kilogram-level annual demand
• Competitive pricing for volume orders and long-term supply agreements
• Lyophilized powder format reduces shipping and storage costs
• Custom packaging and formulation available upon request

Primary Applications

Biopharmaceutical Manufacturing

• Core component of serum-free media for CHO, HEK293, and other mammalian cell lines
• Supports recombinant antibody, fusion protein, and vaccine production
• Compatible with fed-batch and perfusion bioreactor processes
• Improves cell viability and specific productivity in high-density cultures

Cell & Gene Therapy

• Essential supplement for stem cell (MSC, iPSC, HSC) expansion media
• Supports immune cell (CAR-T, NK) cultivation for advanced therapy products
• Compatible with xeno-free and chemically defined media formulations
• Meets raw material requirements for clinical-grade cell products

In Vitro Diagnostics & Life Science Research

• Raw material for iron metabolism assay kits and calibrators
• Affinity purification ligand for anti-transferrin antibody production
• Metal chelation agent for media detoxification and protein stabilization

Emerging Applications

• Cultivated meat / cellular agriculture media formulations
• Bioprinting and tissue engineering culture systems
• Enzyme stabilization and biocatalysis processes

Product Specifications

Important Notice